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In a very pharmacokinetic study of oxycodone in patients with conclusion-phase liver disease, oxycodone plasma clearance lowered and the elimination half-daily life greater.Concomitant utilization of PERCOCET with CYP3A4 inducers or discontinuation of an CYP3A4 inhibitor could minimize oxycodone hydrochloride plasma concentrations, lessen opioid ef

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